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The wild-type enzyme did not hydrolyze the substrate, and thus, the introduction of a single histidine residue transformed the wild-type enzyme into a turnover system for thiol-ester hydrolysis
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Consistent with a recent prospective observational multicenter cohort study, which found that the occurrence of hepatic imAEs was not associated with outcomes in HCC, the differential efficacy between STRIDE and durvalumab monotherapy did not appear to be associated with differences in immune-mediated liver injury, as the incidence of hepatic imAEs was similar across the STRIDE and durvalumab arms
(2017) on IBS and FMT, the authors reported that 28 out of 48 patients (58%) experienced positive outcomes after FMT treatments
